Molecular Screening Platform Kissf

Description

Type of entity	Platform
Main activity	Our facility is specialized in the characterization by screening of small chemical inhibitors of disease- related protein kinases (PKs). A panel of PKs is used to detect new bioactivities of the submitted chemical compounds (synthetic or natural extracts). More precisely, the human kinases selected are therapeutic targets involved notably in mitosis and programmed cell death.
Keywords	Kinases, Pharmacological selectivity, Inhibition, Therapeutic target, Screening, Bbioactivity, Natural molecules
Labels	Biogenouest IBiSA Recognised French National Research Infrastructure (IR) ChemBioFrance
Website Plug in labs Ouest
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Services

Characterization of the bioactivity of molecules Entreprise

Pharmacological selectivity studies Entreprise

Provision of equipment Entreprise

Owned/operated by

Website Roscoff Marine Station

Website The National Center for Scientific Research

Website Sorbonne University

Location and contact

	Send an e-mail
Adress	Place Georges Teissier
Address line 2	Station Biologique de Roscoff - CS 90074
Zip code/Postcode	29688
Town/city	ROSCOFF

Services

Characterization of the bioactivity of molecules Entreprise

Concerned publics	All
Terms of access	Research collaboration access Full service access
Movable ?	yes no
Description	Use of protein kinases as targets of therapeutic interest. The platform offers studies punctuating the "Hit to Lead" strategy. It can perform massive screening of large collections of molecules (collections of more than 10,000 products can be submitted), it can determine 50% inhibitory concentration of activity (IC50) and affinity constants (Kd).

Pharmacological selectivity studies Entreprise

Concerned publics	All
Terms of access	Research collaboration access Full service access
Movable ?	yes no
Description	Studies based on the panel of more than 30 target kinases

Provision of equipment Entreprise

Concerned publics	All
Terms of access	Supervised access Open access
Movable ?	yes no
Description	The KISSf platform provides its equipment. Prior training is provided before use and support is provided by the staff of the platform.

Description

Category	Land-based tests and test sites for engineering and ocean observation Analyses, measurements and metrology
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Scientific disciplines	Telecommunications Molecular biology / Cellular biology
Strategic areas of action	Marine biological resources
Examples of work	ANR OCEANOMICS, BPI France Algolife Institut des Sciences Chimiques de Rennes, Institut de Chimie des Substances Naturelles, North-West University (Afrique du Sud), University College Cork (Irlande), Instituto de Química Médica (Espagne)
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Owned/operated by

Website Roscoff Marine Station
The Roscoff Marine Station is a research and teaching centre for marine biology and ecology. It depends on the CNRS and Sorbonne University.

Website The National Center for Scientific Research
The National Center for Scientific Research

Website Sorbonne University
Sorbonne University is a multidisciplinary, research-intensive and world-class academic institution. Firmly rooted in the heart of Paris, it is committed to the success of its students and devoted to meeting the scientific challenges of the 21st century.